Optimizing curative management of hepatocellular carcinoma

Area of Science:

• Hepatobiliary Medicine
• Surgical Oncology
• Molecular Pathology

Background:

• Hepatocellular carcinoma (HCC) management aims for remission, yet faces high local and distant recurrence rates.
• Histological patterns and molecular subtypes correlate with patient risk for HCC relapse.
• Advances in surgical techniques and percutaneous ablation have improved patient outcomes.

Purpose of the Study:

• To explore strategies for improving remission rates in hepatocellular carcinoma.
• To identify patient subgroups at higher risk of HCC recurrence.
• To discuss the role of molecular subtypes and advanced therapies in HCC management.

Main Methods:

• Analysis of histological patterns linked to molecular subtypes for risk stratification.
• Review of technological advances in surgical techniques and percutaneous ablation for HCC.
• Examination of ongoing trials combining neoadjuvant/adjuvant regimens with standard procedures.

Main Results:

• Histological patterns can identify HCC patient subgroups with higher recurrence risk.
• Improved therapeutic strategies enhance patient outcomes in HCC.
• Controlling underlying liver disease is crucial for reducing late recurrence and preserving liver function.

Conclusions:

• Future HCC therapeutic algorithms may be modified by routine molecular analysis and combined neoadjuvant/adjuvant regimens.
• Personalized treatment strategies based on molecular subtypes are emerging for HCC.
• Continued research into advanced therapies and risk stratification is vital for enhancing HCC patient survival.