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Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
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Mechanism Involved in Fortification by Berberine in CDDP-Induced Nephrotoxicity.

Vipin K Verma1, Salma Malik1, Ekta Mutneja1

  • 1Department of Pharmacology, Cardiovascular Research Laboratory, All India Institute of Medical Sciences, New Delhi, India.

Current Molecular Pharmacology
|February 21, 2020
PubMed
Summary
This summary is machine-generated.

Berberine (Ber) protects against cisplatin-induced kidney damage by activating the Nrf2/HO-1 pathway. This natural compound reduces oxidative stress, inflammation, and apoptosis, preserving kidney function and structure.

Keywords:
BerberineCDDPJNK/p38 MAPKNrf2/HO-1PARPnephrotoxicity

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Area of Science:

  • Pharmacology
  • Toxicology
  • Nephrology

Background:

  • The Nrf2/HO-1 pathway is crucial for mitigating cisplatin-induced nephrotoxicity via antioxidant mechanisms.
  • Berberine (Ber), a natural alkaloid, exhibits known antioxidant, anti-inflammatory, and anti-apoptotic properties.
  • Cisplatin is a widely used chemotherapy agent known to cause significant kidney damage.

Purpose of the Study:

  • To evaluate the protective effects of Berberine against cisplatin-induced kidney injury.
  • To elucidate the underlying molecular mechanisms, particularly the involvement of the Nrf2/HO-1 pathway.

Main Methods:

  • Adult male Wistar rats were administered Berberine orally for 10 days.
  • Nephrotoxicity was induced via a single intraperitoneal injection of cisplatin on day 7.
  • Kidney function, oxidative stress markers, and protein expressions related to inflammation and apoptosis were assessed.

Main Results:

  • Berberine pretreatment significantly improved renal function and preserved kidney architecture compared to cisplatin-only controls.
  • Berberine upregulated Nrf2/HO-1 protein expression, reducing oxidative stress.
  • Berberine attenuated cisplatin-induced inflammation, apoptosis, and autophagy markers (p38/JNK, PARP/Beclin-1).

Conclusions:

  • Berberine effectively protects against cisplatin-induced nephrotoxicity.
  • The protective mechanism involves the activation of the Nrf2/HO-1 pathway and inhibition of JNK/p38MAPKs and PARP/Beclin-1 signaling.
  • Berberine mitigates oxidative stress, inflammation, apoptosis, and autophagy in the renal tissue, offering a potential therapeutic strategy.