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Leukocyte relaxation properties.

K L Sung1, C Dong, G W Schmid-Schönbein

  • 1Department of Physiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

Biophysical Journal
|August 1, 1988
PubMed
Summary
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Leukocyte recovery after deformation is biphasic: a rapid recoil followed by slow spherical shape restoration. Cell activation and pseudopod presence significantly prolong this recovery time.

Area of Science:

  • Biophysics
  • Cell Biology
  • Immunology

Background:

  • Leukocyte mechanical properties are crucial for understanding cell migration and interactions.
  • Leukocytes exhibit viscoelastic behavior, previously studied using micropipette aspiration.
  • Investigating leukocyte shape recovery dynamics provides insights into cellular mechanics.

Purpose of the Study:

  • To analyze the recovery process of leukocytes to their spherical shape after prolonged deformation.
  • To characterize the time-dependent recovery of major (d1) and minor (d2) diameters.
  • To compare recovery dynamics in passive versus activated leukocytes, including those with pseudopods.

Main Methods:

  • Micropipette aspiration technique to deform leukocytes.
  • Monitoring and recording the time history of cell diameters (d1, d2) during recovery.

Related Experiment Videos

  • Observing recovery patterns under different conditions: passive, activated, and with pre-existing pseudopods.

    • Main Results:

    • Leukocyte recovery exhibits an initial rapid recoil followed by a slower, asymptotic return to a spherical shape.
    • Cell activation and pseudopod formation significantly extend the recovery time compared to passive recovery.
    • Recovery initiation is delayed if a pseudopod is present during the deformation period, commencing only upon pseudopod retraction.

    Conclusions:

    • Leukocyte recovery from deformation is a complex, time-dependent process influenced by cellular state.
    • The viscoelastic nature of leukocytes dictates their recovery kinetics.
    • Understanding these recovery dynamics is vital for comprehending leukocyte function in physiological and pathological contexts.