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Nanoparticle-Mediated Visualization and Control of Cellular Membrane Potential: Strategies, Progress, and Remaining
Okhil K Nag1, Megan E Muroski1,2, David A Hastman1,3
1Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, United States.
ACS Nano
|February 21, 2020
Summary
Nanoparticle (NP) materials offer novel ways to visualize and control cellular membrane potential (MP). This review explores NP applications for imaging and modulating electrically excitable cells like neurons.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cell Biology
Background:
- Cellular membrane potential (MP) is crucial in normal physiology and disease.
- Electrically excitable cells (neurons, muscle cells) rely heavily on MP.
- Traditional methods for MP monitoring have limitations.
Purpose of the Study:
- To review the use of nanoparticle (NP) materials for imaging and controlling cellular MP.
- To highlight the advantages of NPs in probing and modulating cell activity.
- To present recent advancements and future perspectives in NP-based MP research.
Main Methods:
- Review of current literature on NP-cell interactions.
- Discussion of NP properties beneficial for MP applications.
- Analysis of case studies demonstrating NP use in visualizing and controlling MP.
Main Results:
- NPs provide unique advantages for MP visualization and control.
- Recent studies showcase successful implementation of NPs in neuroscience and cardiology.
- NP-based approaches offer enhanced precision and functionality compared to traditional methods.
Conclusions:
- Nanoparticle technology is rapidly advancing the field of cellular membrane potential research.
- Future developments will likely focus on sophisticated NP designs for targeted cellular control.
- This field holds significant promise for diagnostics and therapeutics in neurological and cardiac conditions.
