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    A novel robotic system enables precise placement of needle-based therapeutic ultrasound (NBTU) ablators for brain tumor treatment within MRI scanners. This system demonstrates accuracy in preclinical trials, paving the way for improved neurosurgical interventions.

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    Area of Science:

    • Neurosurgery
    • Robotics
    • Medical Imaging

    Background:

    • Brain tumor treatment demands high precision to maximize efficacy and minimize damage to healthy tissue.
    • Needle-based therapeutic ultrasound (NBTU) under real-time MRI guidance offers a precise ablation method.
    • MRI bore's spatial and magnetic constraints hinder precise NBTU tool placement.

    Purpose of the Study:

    • To present preclinical trials of a novel robotic system for NBTU brain tumor ablation.
    • To evaluate the system's accuracy and feasibility for real-time MRI-guided interventions.

    Main Methods:

    • Development of an MRI-compatible robotic manipulator and control system.
    • Integration of NBTU ablation, planning, navigation, and monitoring software.
    • Preclinical testing in gelatin phantoms and porcine brain models.

    Main Results:

    • The robotic system achieved mean translational accuracy of 1.39 ± 0.64 mm in phantoms and 3.13 ± 1.41 mm in porcine trials.
    • Rotational accuracy was 1.27° in phantoms and 5.58° in porcine trials.
    • Maximum signal-to-noise ratio (SNR) reduction was 10.3%.

    Conclusions:

    • The integrated robotic system successfully placed NBTU ablators and enabled real-time monitoring in porcine brains.
    • This system shows potential for clinical translation in neurosurgical procedures.