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Serum Irisin Concentrations in Severely Inflamed Patients
Silvio Buscemi1,2, Davide Corleo1,2, Sonya Vasto3
1Dipartimento di Promozione della Salute, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Inflammation, not just exercise, may increase irisin levels. Severely inflamed patients showed higher irisin concentrations, suggesting a link between inflammation and this myokine.
Area of Science:
- Endocrinology
- Exercise Physiology
- Immunology
Background:
- Irisin is an exercise-induced myokine.
- Irisin is associated with white-to-brown adipose tissue trans-differentiation.
- Previous studies suggested a correlation between irisin and inflammation markers like hs-CRP.
Purpose of the Study:
- To investigate the association between irisin and inflammation.
- To determine if inflammation influences irisin production.
- To test the hypothesis that inflamed patients exhibit high serum irisin levels.
Main Methods:
- Serum irisin concentrations were measured in 40 inflamed inpatients.
- Irisin levels were compared to a population-based cohort (ABCD_2 study).
- Correlations with age, creatinine, fibrinogen, IL-6, and TNF-alpha were analyzed.
Main Results:
- Inflamed patients had significantly higher serum irisin concentrations than the control cohort (6.77 vs. 5.21 ng/ml).
- Irisin levels correlated with age, creatinine, and fibrinogen.
- No association was found between irisin and interleukine-6 or tumor necrosis factor alpha.
Conclusions:
- This study confirms an association between inflammation and irisin concentrations.
- Inflammation may play a role in irisin production.
- Further research is needed to elucidate the mechanisms and clinical implications.
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