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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

340
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
340

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Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin.

Deeb Abu Fara1, Linda Al-Hmoud1, Iyad Rashid2

  • 1Chemical Engineering Department, School of Engineering, University of Jordan, Amman 11942, Jordan.

Marine Drugs
|February 22, 2020
PubMed
Summary
This summary is machine-generated.

Roller compaction transforms raw chitin powder into a suitable excipient for direct compression, improving flow and compressibility. This processed chitin demonstrates comparable performance to microcrystalline cellulose in drug formulations.

Keywords:
Hausner ratioKawakita analysisball millingbulk densitychitincompression workcrushing strengthdirect compressiondissolutionroller compaction

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Area of Science:

  • Materials Science
  • Pharmaceutical Technology
  • Biopolymer Engineering

Background:

  • Chitin, a biopolymer, is explored as a novel excipient for direct compression pharmaceutical formulations.
  • Investigating processing methods to enhance chitin's physical and mechanical properties for pharmaceutical applications is crucial.

Purpose of the Study:

  • To evaluate roller compaction and ball milling as methods for processing chitin into a direct compression excipient.
  • To compare the effects of different processing techniques on chitin's morphology, crystallinity, flowability, and compressibility.
  • To assess the suitability of processed chitin as an excipient in a model drug formulation.

Main Methods:

  • Chitin samples (raw, processed, dried, humidified) were subjected to roller compaction and ball milling.
  • Characterization included morphology analysis, X-ray diffraction, density measurements, FT-IR spectroscopy, and flowability tests.
  • Compressibility and compactibility were evaluated, and a model drug formulation (metronidazole) was prepared.

Main Results:

  • Roller compaction effectively converted raw chitin powder into granules with improved flowability and bulkiness.
  • X-ray diffraction indicated slight crystal lattice deformation with roller compaction, unlike significant crystallinity loss from ball milling.
  • Processed chitin exhibited high compactibility and resistance to compression, attributed to extensive plastic deformation.
  • Drying or humidification did not enhance compressibility or compactibility.
  • Chitin-based formulations showed similar direct compression behavior to microcrystalline cellulose, maintaining immediate drug release.

Conclusions:

  • Roller compaction is a suitable method for producing chitin-based excipients for direct compression.
  • Processed chitin offers improved flow and excellent compactibility, comparable to established excipients like microcrystalline cellulose.
  • Chitin holds promise as a novel, functional excipient in pharmaceutical formulations, particularly for immediate-release solid dosage forms.