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G-Protein Gated Ion Channels

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GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...

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Related Experiment Video

Updated: Dec 28, 2025

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

Published on: February 22, 2022

TRPC Channels in Cardiac Plasticity.

Takuro Numaga-Tomita¹, Motohiro Nishida^2,3,4

¹Department of Molecular Pharmacology, Shinshu University School of Medicine and Health Sciences, Matsumoto 390-8621, Japan.

|February 22, 2020

Summary

This summary is machine-generated.

The heart

Keywords:

TRPC channel calcium signaling cardiac plasticity

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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

Area of Science:

Cardiovascular Biology
Cellular Physiology

Background:

The heart adapts its structure to meet bodily demands, a process crucial for maintaining function.
While physiological adaptations are reversible, chronic stress leads to irreversible cardiac remodeling and heart failure.
Calcium dyshomeostasis and reactive oxygen species are implicated in pathological cardiac remodeling.

Purpose of the Study:

To review the role of Canonical Transient Receptor Potential (TRPC) channels in cardiac plasticity.
To explore how TRPC channels mediate the heart's flexible structural changes in response to environmental stresses.
To identify future research directions concerning TRPC channels in cardiac remodeling.

Main Methods:

Literature review of recent findings on TRPC channels in cardiac physiology and pathology.
Analysis of studies investigating TRPC channel function in response to mechanical loading and other stresses.
Synthesis of evidence linking TRPC channels to calcium handling and reactive oxygen species production in cardiomyocytes.

Main Results:

TRPC channels are important modulators of cardiac plasticity, influencing structural adaptations.
Evidence suggests TRPC channels play a role in both physiological and pathological cardiac remodeling.
Aberrant TRPC channel activity may contribute to irreversible heart damage under chronic stress.

Conclusions:

TRPC channels are key players in the heart's ability to adapt its structure (cardiac plasticity).
Understanding TRPC channel function is vital for developing strategies against heart failure caused by chronic stress.
Further research is needed to fully elucidate the mechanisms and therapeutic potential of TRPC channels in cardiac remodeling.