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Published on: May 19, 2023
Intracellular Mechanisms of Oxygen Sensing
A N Vjotosh1,2,3
1Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, 194223, Russia. vjotnn@yahoo.com.
Abstract:
The review describes molecular mechanisms for sensing oxygen levels in various compartments of animal cell. Several pathways for intracellular oxygen sensing are discussed together with details of functioning of the near-membrane and cytoplasmic pools of molecular components in hypoxic cells. The data on the role of mitochondria in cell sensitivity to a decreased oxygen content are presented. Details of mutual influence of the operational and chronic intracellular mechanisms for detecting the negative gradients of molecular oxygen concentration and their relationship with cell metabolism response to the oxidative stress are discussed.
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