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Updated: Jun 25, 2026
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Access-Site Complications in Mechanical Thrombectomy for Acute Ischemic Stroke: A Review of Prospective Trials
S Z Shapiro1, K A Sabacinski1, K Mantripragada1
1From Florida Atlantic University Charles E. Schmidt College of Medicine (S.Z.S., K.A.S., K.M., N.B.E., G.A.M., B.M.S.), Boca Raton, Florida.
Background:
A shift has occurred in interventional cardiology from transfemoral to transradial access due to a 70%-80% decrease in complications. This shift has not yet taken place in other interventional specialties, perhaps owing to the lack of generalizability of findings in the cardiology data.
Purpose:
Our aim was to assess data from the recent mechanical thrombectomy prospective trials to better understand the access-site complication rate.
Data Sources:
Articles were systematically sourced from the National Center for Biotechnology Information PubMed archive.
Study Selection:
According to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, prospective, randomized controlled trials published after 2008 with mention of major and/or minor femoral access-site complications in neuroendovascular mechanical thrombectomies were included.
Data Analysis:
Major and minor femoral access-site complications were extracted. A total complication rate was calculated with major access-site complications alone and combined with minor access-site complications.
Data Synthesis:
Seven prospective studies of 339 total screened met the inclusion criteria. Eleven major access-site complications were identified in of 660 total interventions, revealing a major access-site complication rate of 1.67% for patients undergoing mechanical thrombectomy with transfemoral access. If minor access-site complications were included, 35 total incidents were detected in 763 interventions, resulting in a total complication rate of 4.59%.
Limitations:
Multiple unspecified vessel and procedure-related complications were mentioned in the studies.
Conclusions:
The overall rate of major access-site complications was 1.67% in this review, which is not low and poses a risk to patients. We suggest further investigation into the feasibility and complication rates of alternative access sites for neurointerventional procedures.
