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Published on: June 2, 2023

Decrease in serum testosterone levels after short-term occupational exposure to diisononyl phthalate in male workers.

Jean-Bernard Henrotin¹, Eva Feigerlova², Alain Robert³

¹Occupational Epidemiology Division, National Research and Safety Institute, Vandoeuvre-Les-Nancy, France jeanbernardhenrotin@wanadoo.fr.

Occupational and Environmental Medicine

|February 22, 2020

Summary

This summary is machine-generated.

Occupational exposure to diisononyl phthalate (DINP) was linked to lower testosterone in male workers. This suggests DINP may have weak antiandrogenic effects, requiring further investigation.

Keywords:

endocrine disorders exposure assessment hygiene / occupational hygiene male reproduction occupational health practice

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Area of Science:

Endocrinology
Occupational Health
Environmental Science

Background:

Phthalates, including diisononyl phthalate (DINP), are widely used industrial chemicals.
Concerns exist regarding the potential endocrine-disrupting effects of phthalates on human health.
Occupational exposure to DINP may pose risks to reproductive health in male workers.

Purpose of the Study:

To investigate the association between occupational exposure to diisononyl phthalate (DINP) and serum testosterone levels in male workers.
To explore potential antiandrogenic properties of DINP in an industrial setting.
To assess the impact of DINP on reproductive and bone health markers.

Main Methods:

A short longitudinal study involving 97 male workers in the French plastics industry.
Measurement of serum total and free testosterone, reproductive hormones, and bone turnover markers.
Assessment of DINP exposure via urinary metabolites (OXO-MINP, OH-MINP, CX-MINP).
Analysis of erectile dysfunction using standardized questionnaires and statistical modeling.

Main Results:

Increased urinary OXO-MINP levels correlated with decreased total serum testosterone in workers with lower exposure levels (p=0.002).
A non-significant trend of decreased testosterone was observed with higher CX-MINP.
Workers with direct DINP exposure reported more erectile problems (p=0.01).

Conclusions:

Short-term occupational exposure to DINP is associated with reduced total serum testosterone in male workers.
The findings suggest potential weak antiandrogenic properties of DINP in humans.
Further research is needed to confirm these effects and their clinical significance.