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Radiation-induced changes in mouse duodenal papilla.
The British Journal of Radiology
|November 1, 1988
Summary
X-ray irradiation significantly alters the duodenal papilla structure in mice. This change, observed three days post-treatment, may impact pancreatic and biliary secretion flow.
Area of Science:
- Gastroenterology
- Radiation Biology
- Anatomy
Background:
- Radiation effects on duodenal morphology are documented.
- Post-irradiation changes in the duodenal papilla remain uninvestigated.
Purpose of the Study:
- To investigate the effects of X-ray irradiation on the structure of the duodenal papilla.
Main Methods:
- Mice were irradiated with 15 Gy X rays.
- Duodenal papilla morphology and location were examined 18 hours and 3 days post-irradiation using scanning electron microscopy.
Main Results:
- The duodenal papilla was difficult to locate in untreated mice.
- Eighteen hours post-irradiation, minimal changes were observed.
- Three days post-irradiation, the papilla became more prominent, shifted closer to the pylorus, and exhibited a dilated orifice.
Conclusions:
- X-ray irradiation alters duodenal papilla structure.
- These alterations may affect duodenal function, particularly the control of pancreatic and biliary secretions.