Related Experiment Video

Updated: Dec 28, 2025

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

4.4K

A statistical analysis of the correlations among various types of clinical indexes for patients with chronic

Jie Wang1, Yonglan Pu, Yinhua Gong

  • 1Taicang Affiliated Hospital of Soochow University, The First People's Hospital of Taicang, Suzhou, Jiangsu Province, China.

Medicine
|February 22, 2020
PubMed

Insights

This study reveals that gender significantly impacts liver stiffness measurements in Hepatitis B virus (HBV) patients and healthy individuals. Key biochemical markers like bilirubin and aminotransferases are associated with HBV diagnosis.

Area of Science:

  • Hepatology
  • Virology
  • Biochemistry

Background:

  • Hepatitis B virus (HBV) infection represents a significant global health burden, particularly in Asia and Africa.
  • Despite advancements in early detection and care, the influence of demographic factors like gender and age on HBV patient parameters requires further investigation.
  • Understanding these relationships is crucial for refining diagnostic and prognostic tools in hepatology.

Purpose of the Study:

  • To investigate the correlations between various physiological and biochemical indexes in a large cohort of HBV patients and healthy controls.
  • To examine the impact of gender and age on liver stiffness measurement (LSM) and controlled attenuation parameters (CAPs).
  • To compare the diagnostic values of these parameters for hepatic fibrosis in HBV patients.

Main Methods:

  • Measurement of physiological and biochemical indexes in HBV patients and healthy controls.
  • Correlation analysis of indexes and imaging results.
  • Group comparisons based on gender and age for LSM and CAPs.
  • Evaluation of diagnostic values for hepatic fibrosis.

Main Results:

  • HBV patient samples clustered differently from healthy controls, indicating distinct physiological profiles.
  • Direct bilirubin (DB), total bilirubin (TB), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were associated with HBV diagnosis.
  • Gender significantly affected fibrotouch measurements in both HBV patients and healthy controls.

Conclusions:

  • Demographic factors, specifically gender, play a significant role in liver stiffness measurements, impacting diagnostic accuracy.
  • Biochemical markers like bilirubin and aminotransferases are important indicators in HBV diagnosis.
  • Further research is needed to refine critical values for medical indexes based on these influencing parameters.

More Related Videos

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques11:28

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

41.3K
Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

18.8K

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
130
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
167