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Effects of vitamin C supplementation on essential hypertension: A systematic review and meta-analysis

Yuanyuan Guan1, Pengju Dai2, Hongwu Wang3

  • 1Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin.

Medicine
|February 22, 2020
PubMed

Insights

Vitamin C (VitC) supplementation significantly reduced blood pressure in patients with essential hypertension. This meta-analysis of randomized controlled trials found notable decreases in both systolic and diastolic blood pressure.

Area of Science:

  • Cardiovascular Health
  • Nutritional Science
  • Clinical Research

Background:

  • The potential of Vitamin C (VitC) supplementation for managing hypertension is debated.
  • Evidence on VitC's efficacy in primary hypertension patients requires systematic evaluation.

Purpose of the Study:

  • To systematically analyze the impact of Vitamin C (VitC) supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP).
  • To assess VitC's effect on blood pressure in individuals diagnosed with essential hypertension.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases including PubMed, EMBASE, Cochrane Library, and Chinese databases until June 2019.
  • Eight randomized controlled trials (RCTs) with 614 participants were included in the meta-analysis.
  • Risk of bias was assessed using the Cochrane Collaboration tool, and data were analyzed using Review Manager 5.3.

Main Results:

  • VitC supplementation demonstrated a significant reduction in both SBP (WMD = -4.09 mmHg) and DBP (WMD = -2.30 mmHg).
  • Subgroup analyses revealed significant SBP reductions in participants aged ≥60 years and in studies with ≥35 participants.
  • Significant SBP reductions were also observed in studies with a duration of ≥6 weeks and VitC doses of ≥500 mg daily.

Conclusions:

  • Vitamin C supplementation is effective in significantly lowering blood pressure among patients with essential hypertension.
  • The findings support the use of VitC as a potential adjunctive therapy for hypertension management.
Abstract

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