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Asprosin and type 2 diabetes mellitus: a novel potential therapeutic implication

P Bhadel1, S Shrestha2,3, B Sapkota4

  • 1Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China.

Journal of Biological Regulators and Homeostatic Agents
|February 22, 2020
PubMed

Insights

Asprosin, a hormone linked to fasting, is elevated in type 2 diabetes (T2DM) and impaired glucose regulation. Targeting asprosin may offer new therapeutic strategies for T2DM and obesity management.

Area of Science:

  • Endocrinology and Metabolism
  • Molecular Biology

Background:

  • Diabetes Mellitus (DM) is a metabolic disorder characterized by hyperglycemia, increasing risks of cardiovascular and microvascular complications.
  • Type 2 Diabetes Mellitus (T2DM) pathogenesis involves complex mechanisms, with ongoing research into novel therapeutic targets.
  • Asprosin, a hormone encoded by the FBN1 gene, is secreted by white adipose tissue during fasting.

Discussion:

  • Asprosin acts on the liver via cell membrane receptors, activating the G protein cAMP-PKA pathway.
  • Increased asprosin secretion during fasting serves as a compensatory mechanism for hypoglycemia.
  • Elevated asprosin concentrations are observed in patients with T2DM and impaired glucose regulation.

Key Insights:

  • Asprosin levels are significantly higher in individuals with T2DM compared to healthy controls.
  • Genetic deficiency in asprosin is associated with appetite issues and extreme leanness.
  • Asprosin represents a potential novel therapeutic target for T2DM and obesity.

Outlook:

  • Modulating asprosin activity or levels could lead to innovative treatments for diabetes management.
  • Further research into asprosin's role in metabolic disorders is warranted.
  • Asprosin may serve as a key biomarker and therapeutic target for future diabetes interventions.
Keywords:
adipokineasprosinprotein hormonetype 2 diabetes

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