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Prevalence of Human Metapneumovirus Infections in Iran: A Systematic Review and Meta-Analysis

Somayeh Shatizadeh Malekshahi1, Jila Yavarian2, Nazanin-Zahra Shafiei-Jandaghi2

  • 1Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Fetal and Pediatric Pathology
|February 22, 2020
PubMed

Insights

This study found human metapneumovirus (hMPV) has an intermediate prevalence in Iran, affecting 8.9% of the population, particularly children. Further research is needed to understand its distribution and genotypes across the country.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Human metapneumovirus (hMPV) is an important respiratory pathogen.
  • Understanding hMPV prevalence in Iran is crucial for public health strategies.
  • Previous data on hMPV epidemiology in Iran is fragmented.

Purpose of the Study:

  • To systematically review and meta-analyze the prevalence of hMPV infections in Iran.
  • To consolidate existing epidemiological data on hMPV in the Iranian population.
  • To compare Iranian hMPV prevalence with global rates.

Main Methods:

  • Comprehensive literature search of multiple databases (PubMed, Scopus, Web of Science, etc.) and Persian national databases.
  • Inclusion of studies on hMPV epidemiology in Iran published up to June 2019.
  • Meta-analysis to estimate pooled prevalence rates and confidence intervals.

Main Results:

  • The overall estimated prevalence of hMPV in Iran was 8.9% (95% CI 5.4-14.2).
  • hMPV prevalence in Iran is intermediate compared to global estimates.
  • Pediatric populations showed a pooled prevalence of 7.6% (I² = 95%) for hMPV infections.

Conclusions:

  • This meta-analysis provides the first comprehensive overview of hMPV epidemiology in Iran over an 11-year period.
  • hMPV is circulating in Iran with a notable prevalence, especially in children.
  • Further large-scale epidemiological studies are recommended to assess prevalence and genotype distribution in understudied regions of Iran.
Keywords:
Iranepidemiologyhuman metapneumovirusinfectionsmeta-analysisprevalencesystematic review

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