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Practice patterns in older patients with diffuse large B-cell lymphoma: A medicare analysis, 2007-2015

Elizabeth Levin1, Yi Peng2, Yuanyuan Ji2

  • 1Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street S.E, Mayo Mail Code 480, Minneapolis, MN 55455, United States of America.

Journal of Geriatric Oncology
|February 22, 2020
PubMed
Summary

No abstract available in PubMed .

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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