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The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review

K Sun1, J Luo2, J Guo1

  • 1Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.

Osteoarthritis and Cartilage
|February 22, 2020
PubMed

Insights

Osteoarthritis (OA) involves joint tissue degeneration. Targeting the PI3K/AKT/mTOR pathway shows promise for novel OA treatments by addressing cartilage and bone issues.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Rheumatology

Background:

  • Osteoarthritis (OA) is a degenerative joint disease with limited effective treatments beyond surgery.
  • The PI3K/AKT/mTOR signaling pathway plays a crucial role in joint tissue metabolism and OA development.

Purpose of the Study:

  • To comprehensively review the roles of the PI3K/AKT/mTOR pathway in osteoarthritis.
  • To explore therapeutic strategies targeting this pathway for OA treatment.

Main Methods:

  • A comprehensive literature search was conducted using PubMed.
  • Keywords included 'PI3K OR AKT OR mTOR' and 'osteoarthritis'.

Main Results:

  • The PI3K/AKT/mTOR pathway is implicated in cartilage degradation, subchondral bone dysfunction, and synovial inflammation in OA.
  • Emerging evidence suggests targeting this pathway offers potential therapeutic benefits for OA.

Conclusions:

  • The PI3K/AKT/mTOR pathway is a key factor in OA pathogenesis.
  • Targeting this pathway presents a promising avenue for developing new OA treatments, though clinical challenges remain.
Keywords:
AKTCartilageOsteoarthritisPI3KmTOR

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