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Cyclophosphamide-Induced Tolerance in Allogeneic Transplantation: From Basic Studies to Clinical Application
Koji Kato1, Ario Takeuchi2, Koichi Akashi1
1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Frontiers in Immunology
|February 22, 2020
Summary
Cyclophosphamide (Cy)-induced immune tolerance is crucial for successful organ and stem cell transplantation. Posttransplant Cy has proven effective in clinical practice, translating basic research into patient benefits.
Area of Science:
- Immunology
- Transplantation Science
Background:
- Immune tolerance to alloantigens is vital for clinical organ and hematopoietic stem cell transplantation success.
- Mixed chimerism is essential for inducing and maintaining immune tolerance.
- Cyclophosphamide (Cy)-induced tolerance has been studied in murine models since the early 1980s.
Purpose of the Study:
- To review studies on cyclophosphamide (Cy)-induced immune tolerance.
- To highlight the translation of basic research into clinical practice for transplantation.
Main Methods:
- Focus on a review of existing literature on Cy-induced immune tolerance.
- Analysis of clinical data from allogeneic transplantation patients.
Main Results:
- Cyclophosphamide (Cy) is a key factor in inducing immune tolerance.
- Posttransplant Cy has demonstrated successful clinical application.
Conclusions:
- Cyclophosphamide (Cy)-induced immune tolerance is a critical component in transplantation.
- The posttransplant Cy approach effectively bridges basic science discoveries with clinical outcomes.
Keywords:
allogeneic hematopoietic stem cell transplantationcyclophosphamidegraft-vs.-host diseasekidney transplantationtoleranceMore Related Videos
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