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Evaluation of Extracellular Vesicle Function During Malaria Infection
13:45

Evaluation of Extracellular Vesicle Function During Malaria Infection

Published on: February 14, 2018

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Role of Extracellular Vesicles in Cellular Cross Talk in Malaria

Kehinde Adebayo Babatunde1,2, Bibin Yesodha Subramanian2, Ambroise Dioum Ahouidi3,4

  • 1Center for Engineering in Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.

Frontiers in Immunology
|February 22, 2020
PubMed

Insights

Extracellular vesicles (EVs) from malaria-infected cells regulate disease severity and parasite transmission. These EVs mediate communication between host and parasite, influencing malaria outcomes.

Area of Science:

  • Parasitology
  • Immunology
  • Cell Biology

Background:

  • Malaria, caused by Plasmodium species, presents variable disease severity.
  • Host-parasite interactions critically determine malaria outcomes.
  • Extracellular vesicles (EVs) are emerging as key mediators in host-parasite communication.

Purpose of the Study:

  • To review recent advancements in understanding the roles of EVs in malaria.
  • To highlight how EVs regulate the balance between host and parasite factors.
  • To explore EV-mediated communication in malaria pathogenesis and transmission.

Main Methods:

  • Literature review of recent research on extracellular vesicles in malaria.
  • Analysis of studies investigating EV cargo and function.
  • Synthesis of findings on EV-mediated host-parasite interactions.

Main Results:

  • EVs secreted by infected red blood cells (iRBCs) and other host cells modulate malaria disease severity.
  • EVs facilitate cell-to-cell communication by transferring proteins, lipids, DNA, and RNA.
  • EV cargo influences host immune responses and parasite transmission stages.

Conclusions:

  • Extracellular vesicles play a significant role in regulating malaria pathogenesis.
  • EVs are crucial for intercellular communication, impacting both host and parasite.
  • Further research into EVs offers potential for novel malaria control strategies.
Keywords:
InfectionMalariaPlasmodium faciparumcellular communicationextracellular vesicles

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