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Self-Assemblable Polymer Smart-Blocks for Temperature-Induced Injectable Hydrogel in Biomedical Applications.

Thai Thanh Hoang Thi1, Le Hoang Sinh2, Dai Phu Huynh3

  • 1Biomaterials and Nanotechnology Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

Frontiers in Chemistry
|February 22, 2020
PubMed
Summary

Researchers developed self-assembling polymer smart-blocks for temperature-induced injectable hydrogels. These hydrogels are promising for controlled drug delivery and tissue engineering applications.

Keywords:
biomaterialsblock copolymerdrug delivery systemhydrogelsinjectableself-assemblytemperature-sensitivetissue engineering

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Self-assembled hydrogels are crucial for drug delivery and tissue regeneration.
  • Polymer smart-blocks enable hydrogel formation through self-assembly in response to stimuli.
  • Stimuli include temperature, pH, and light, inducing changes in polymer properties.

Purpose of the Study:

  • To review the development of self-assembly smart-blocks for temperature-induced injectable hydrogels.
  • To explore their potential in drug delivery systems.
  • To highlight their application as platforms for tissue engineering.

Main Methods:

  • Fabrication of injectable hydrogels via self-assembly of polymer smart-blocks.
  • Utilizing temperature as the primary stimulus for hydrogel gelation.
  • Investigating the self-assembly behavior of copolymers in aqueous solutions.

Main Results:

  • Polymer smart-blocks self-assemble to form physically cross-linked hydrogels.
  • These hydrogels can transition from solution to gel state in response to temperature changes.
  • The hydrogels are suitable for loading bioactive molecules and cells.

Conclusions:

  • Self-assembly smart-blocks are effective for creating temperature-induced injectable hydrogels.
  • These hydrogels show significant potential for controlled drug release.
  • They serve as versatile biomaterial scaffolds for tissue regeneration.