Related Experiment Video

Updated: Dec 28, 2025

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

924

Maternal obesity influences the endocrine cord blood profile of their offspring

Carolina Carvalho Mocarzel1, Guillermo Coca Velarde2, Roberto de Azevedo Antunes3

  • 1Federal Fluminense University, Post-Graduation in Medical Sciences, Niteroi, RJ, Brazil.

Journal of Perinatal Medicine
|February 22, 2020
PubMed

Insights

Offspring from obese mothers had lower cord blood glucose and triglycerides compared to healthy controls. Maternal obesity was also linked to reduced cholesterol and HDL-C in mothers.

Area of Science:

  • Endocrinology
  • Neonatal Health
  • Maternal-Fetal Medicine

Background:

  • Maternal obesity is a growing concern with potential impacts on offspring health.
  • Understanding the endocrine profile of neonates born to obese mothers is crucial for early intervention.

Purpose of the Study:

  • To compare cord blood endocrine characteristics in neonates born to obese mothers versus those born to healthy mothers.
  • To investigate the association between maternal obesity and neonatal metabolic markers.

Main Methods:

  • A cross-sectional case-control study was conducted.
  • Cord blood samples were collected from neonates of obese mothers (n=41) and healthy controls (n=31).
  • Analyzed cord blood levels of glucose, insulin, total cholesterol, triglycerides, HDL-C, and LDL-C.

Main Results:

  • Neonates of obese mothers exhibited significantly lower cord blood glucose (47.8 mg/dL vs. 57.9 mg/dL) and triglycerides (26.5 mg/dL vs. 34.6 mg/dL).
  • Maternal obesity was associated with reduced maternal total cholesterol and HDL-C levels.
  • No significant difference in cord blood insulin or LDL-C was reported.

Conclusions:

  • Maternal obesity is associated with altered cord blood metabolic profiles in neonates, specifically lower glucose and triglycerides.
  • These findings highlight potential long-term metabolic implications for offspring of obese mothers.
  • Further research is warranted to explore the mechanisms and clinical significance of these observations.

Keywords:
cholesterolcord bloodmaternal obesityoffspring obesity

More Related Videos

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

977
Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

704

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.9K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.6K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
125
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
190