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Impact of coronary involvement on long-term outcomes in patients with Takayasu's arteritis

Hui Wang1, Zhenyu Liu2, Zhujun Shen1

  • 1Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Clinical and Experimental Rheumatology
|February 22, 2020
PubMed

Insights

Coronary involvement in Takayasu

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Vascular Biology

Background:

  • Takayasu's arteritis (TAK) is a large vessel vasculitis.
  • Coronary artery involvement is a significant complication of TAK.
  • Predicting coronary involvement and its impact on outcomes is crucial for patient management.

Purpose of the Study:

  • To identify predictors of coronary involvement in TAK patients.
  • To determine the impact of coronary involvement on long-term outcomes.
  • To analyze factors influencing survival and disease relapse in TAK.

Main Methods:

  • Retrospective cohort study of 130 TAK patients.
  • Coronary evaluation via angiography or CT angiography.
  • Analysis of risk factors and survival predictors over a median follow-up of 4.3 years.

Main Results:

  • Over half (54.6%) of TAK patients had coronary involvement.
  • Increasing age and Type V angiographic classification predicted coronary involvement.
  • Coronary involvement, LV systolic dysfunction, and aortic regurgitation predicted overall survival.
  • Coronary involvement and active disease predicted major cardiovascular events and relapse.

Conclusions:

  • Coronary involvement is a key predictor of poor long-term outcomes in TAK.
  • Age and Type V classification aid in identifying TAK patients with coronary involvement.
  • Early identification and management of coronary involvement are vital for improving TAK patient prognosis.
Abstract

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