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Quantifying Cortical Resilience in Experimental, Clinical, and Epidemiological Studies: A Conceptually Grounded
Peter A Hall1, Kirk I Erickson, Cassandra J Lowe
1From the Prevention Neuroscience Laboratory, Faculty of Applied Health Sciences (Hall, Sakib), University of Waterloo, Waterloo; Department of Psychology (Erickson), University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Psychology, Brain and Mind Institute (Lowe), Western University, London, Ontario, Canada.
Cortical resilience, the brain cortex's ability to recover from disruption, can now be measured. The Cortical Challenge and Recovery Test (CCaRT) offers a standardized method for assessing this crucial brain function.
Area of Science:
- Neuroscience
- Cognitive Science
Background:
- Cortical resilience, the brain's capacity to rebound from perturbation, is vital in research and clinical settings.
- Currently, no direct measure exists to quantify cortical resilience.
- Repetitive transcranial magnetic stimulation (rTMS) offers a standardized method to induce controlled perturbations.
Purpose of the Study:
- To describe a standardized method for quantifying cortical resilience.
- To introduce the Cortical Challenge and Recovery Test (CCaRT) as a novel measure.
Main Methods:
- Utilizes inhibitory variants of rTMS, specifically continuous theta burst stimulation (cTBS), to induce a cortical perturbation.
- Assesses the rate of recovery from the induced perturbation.
- Integrates existing stimulation parameters and cognitive testing paradigms.
Main Results:
- The developed method, CCaRT, provides a flexible and conceptually meaningful measure of cortical resilience.
- CCaRT leverages established stimulation and cognitive testing protocols.
Conclusions:
- The CCaRT paradigm offers a standardized approach to measuring cortical resilience.
- CCaRT is applicable to diverse research and clinical contexts, including epidemiological studies, laboratory experiments, diagnostic practices, and clinical trial outcome measures.
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