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Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes

Eri Takematsu1, Adrianne Spencer1, Jeff Auster1

  • 1University of Texas at Austin, Department of Biomedical Engineering, Austin, TX.

Plos One
|February 22, 2020
PubMed

Insights

Diabetic skin shows altered gene expression, potentially revealing causes of non-healing chronic ulcers. This research may identify new therapeutic targets for diabetic complications.

Area of Science:

  • Molecular biology
  • Genomics
  • Dermatology

Background:

  • Non-healing chronic ulcers are a significant complication of diabetes, posing a major healthcare challenge.
  • Current treatments for diabetic ulcers lack consistent efficacy in clinical trials.
  • Understanding molecular changes in diabetic skin may elucidate ulcer formation mechanisms.

Purpose of the Study:

  • To investigate genome-wide gene expression differences in skin between type 2 diabetes patients and non-diabetic individuals.
  • To identify potential causal factors and therapeutic targets for diabetic-related skin complications.

Main Methods:

  • Utilized next-generation sequencing to analyze gene expression.
  • Compared gene expression profiles in skin samples from 27 participants (13 with type 2 diabetes, 14 non-diabetic).

Main Results:

  • Genome-wide gene expression analysis revealed significant differences in skin gene expression between diabetic and non-diabetic patients.
  • Identified specific genes and pathways affected by type 2 diabetes in skin tissue.

Conclusions:

  • Altered gene expression in the skin of type 2 diabetes patients may contribute to the development of non-healing chronic ulcers.
  • Findings provide a foundation for identifying novel therapeutic targets for preventing and treating diabetic skin complications.

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