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Weighted gene co-expression network analysis identified six hub genes associated with rupture of intracranial

Qunhui Wang1, Qi Luo1, Zhongxi Yang1

  • 1Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin, P. R. China.

Plos One
|February 22, 2020
PubMed

Insights

Researchers identified key genes linked to ruptured intracranial aneurysms (IAs). These findings offer insights into IA progression and potential biomarkers for rupture risk assessment.

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Intracranial aneurysms (IAs) involve cerebral artery dilation and can lead to subarachnoid hemorrhage, increasing disability and mortality risks.
  • Understanding the pathogenesis of ruptured IAs is crucial for improving patient outcomes and developing predictive tools.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying ruptured intracranial aneurysms (IAs).
  • To identify potential hub genes that could serve as biomarkers for IA progression and rupture prediction.

Main Methods:

  • Reanalysis of GSE36791 and GSE73378 datasets from the National Center of Biotechnology Information Gene Expression Omnibus.
  • Weighted gene co-expression network analysis to correlate gene sets with clinical features of IA rupture.
  • Validation of potential biomarker gene expression using quantitative real-time PCR.

Main Results:

  • Identification of 14 co-expression modules and 238 hub genes associated with intracranial aneurysms.
  • Three specific modules (turquoise, blue, brown) showed a strong correlation with IA rupture events.
  • Six candidate biomarkers (BASP1, CEBPB, ECHDC2, GZMK, KLHL3, SLC2A3) were identified as significantly associated with IA progression and rupture.

Conclusions:

  • The study provides novel insights into the molecular pathogenesis of intracranial aneurysms.
  • Identified hub genes, particularly BASP1, CEBPB, ECHDC2, GZMK, KLHL3, and SLC2A3, show potential as biomarkers for monitoring IA rupture risk.

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