Aging Biomarkers: From Functional Tests to Multi-Omics Approaches

Area of Science:

• Gerontology and Biomarker Research
• Molecular Biology and Aging
• Chronobiology and Healthspan

Background:

• Aging causes detrimental physiological changes, impacting function and increasing chronic disease risk.
• Accurate assessment of the aging process requires sophisticated methods beyond disease diagnosis.
• Developing reliable biomarkers is crucial for quantifying aging at cellular, tissue, and organismal levels.

Purpose of the Study:

• To provide an updated overview of human aging biomarkers.
• To emphasize biomarkers reflecting individual aging mechanisms.
• To outline future directions in aging assessment.

Main Methods:

• Review of classical discrete molecular and non-molecular aging biomarkers.
• Inclusion of emerging omics-based biomarkers.
• Analysis of biomarkers correlating strongly with chronological age.

Main Results:

• Identification of established biomarkers with strong age correlation.
• Discussion of novel omics-based biomarkers for aging assessment.
• Highlighting the importance of personalized aging mechanisms.

Conclusions:

• Biomarkers are essential for quantifying human aging progression.
• Future research should focus on personalized aging biomarkers.
• Advanced omics technologies offer promising avenues for aging assessment.