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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
660

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Layer-by-Layer Biomaterials for Drug Delivery.

Dahlia Alkekhia1, Paula T Hammond2, Anita Shukla1,3

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Annual Review of Biomedical Engineering
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Summary

Layer-by-layer (LbL) self-assembly creates advanced drug delivery coatings. These versatile biomaterials offer controlled release for conditions like cancer and infections, showing promise in clinical applications.

Keywords:
antibacterial materialscancer therapycellular engineeringcontrolled drug deliverylayer-by-layer self-assemblypolyelectrolyte multilayer films

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Controlled drug delivery formulations are crucial for treating various health conditions.
  • Layer-by-layer (LbL) self-assembly is a versatile fabrication method for drug release coatings.
  • LbL coatings offer advantages like preserving therapeutic agent activity and coating diverse substrates.

Purpose of the Study:

  • To review recent advancements in LbL-engineered biomaterials for drug delivery.
  • To highlight the potential of LbL coatings in cancer therapy, infection treatment, and cellular response modulation.
  • To discuss the advantages of LbL biomaterial design through in vitro and in vivo evidence.

Main Methods:

  • Review of recent literature on LbL self-assembly for drug delivery.
  • Analysis of LbL film properties and their relation to controlled release.
  • Evaluation of LbL-engineered biomaterials in cancer therapy, infection control, and regenerative medicine.

Main Results:

  • LbL self-assembly enables the development of multifunctional controlled drug release coatings.
  • LbL coatings can incorporate and preserve biological activity of therapeutics.
  • These coatings demonstrate tunable, targeted, and responsive drug release profiles.
  • LbL biomaterials show potential in cancer therapy, infection prevention/treatment, and directing cellular responses.

Conclusions:

  • LbL self-assembly is a powerful technique for creating advanced drug delivery systems.
  • LbL-engineered biomaterials offer significant advantages for diverse therapeutic applications.
  • Further in vitro and in vivo studies confirm the efficacy and versatility of LbL-based drug delivery.