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Epigenetics, Development, and Psychopathology.

Kieran J O'Donnell1,2,3, Michael J Meaney1,3,4,5

  • 1Department of Psychiatry and Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec H4H 1R3, Canada;

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|February 22, 2020
PubMed
Summary
This summary is machine-generated.

Environmental factors impact gene expression through epigenetic mechanisms. This review explores epigenetics in brain function and psychopathology, highlighting its clinical relevance in mental health.

Keywords:
early experienceepigeneticsgene transcriptiongene × environment interactionsneurodevelopmentpsychopathology

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychology

Background:

  • Epigenetic mechanisms regulate genome transcription.
  • Environmental conditions influence epigenetic mechanisms affecting gene expression and neural function.
  • Rodent models provide insights into epigenetic regulation.

Purpose of the Study:

  • To review epigenetic mechanisms and their role in interindividual differences in gene expression.
  • To emphasize translational research in epigenetics for psychopathology.
  • To discuss the integration of epigenetics into developmental and clinical psychology.

Main Methods:

  • Overview of epigenetic mechanisms.
  • Review of rodent model research.
  • Emphasis on translational research programs.

Main Results:

  • Environmental factors can directly alter epigenetic mechanisms.
  • Epigenetics contributes to interindividual differences in brain and neural function.
  • Translational research is advancing the understanding of epigenetics in psychopathology.

Conclusions:

  • Epigenetics holds significant translational relevance for studying psychopathology.
  • Further research is needed to integrate epigenetics into clinical psychology and mental health practice.
  • Understanding epigenetic influences is crucial for future mental health research and treatment.