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Updated: Aug 12, 2026

Immunolabelling Myofiber Degeneration in Muscle Biopsies
Published on: December 5, 2019
Distal myopathy with focal granular degenerative change in vacuolated type 2 fibers
M Swash1, M S Schwarz, A Thompson
1Department of Neurology, London Hospital, UK.
Abstract:
A slowly progressive distal myopathy with raised blood (CK) level commencing in the second decade was associated with large vacuoles found only in type 2 fibers. The vacuoles consisted of sarcoplasmic spaces without limiting membranes, containing granular and fibrillar material. This material probably represented degenerative products derived from myofibrils. A distinction is drawn between these degenerative vacuolar changes and those reported in other cases of sporadic or hereditary distal myopathy in which autophagic vacuoles are characteristic.
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