Influence of metallic carcinogenesis in lung and colorectal neoplasia. Metals in neoplastic processes

We have found changes in the metabolism of trace elements undergoing cancerogenic processes. Using chromatography we have been able to prove that both their distribution among the different plasma proteins and their total concentration in serum and neoplastic tissue are altered. Some differences were found in the values of ceruloplasmin against controls by measuring its oxidizing activity as opposed to O-phenylenediamine. At the same time, using electrophoretic techniques, we have studied the global modifications in the different groups of plasma proteins in neoplastic serum. This report is especially interested in the metabolism of copper, chrome and zinc in serum and tissue in about 20 patients suffering from lung and colorectal neoplasia, in order to compare the parameters which were studied.