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Azlocillin and mezlocillin concentration in human prostatic tissue
R P Smith1, H J Wilbur, C Bassey
1Department of Medicine, Veterans Administration Medical Center, Albany, N.Y.
Chemotherapy
|January 1, 1988
Summary
Azlocillin and mezlocillin achieve therapeutic concentrations in human prostate tissue after standard dosing. These antibiotic levels in prostatic tissue exceed the minimum inhibitory concentrations for common bacterial pathogens.
Area of Science:
- Pharmacology
- Urology
- Infectious Diseases
Background:
- Bacterial prostatitis is a common condition requiring effective antibiotic treatment.
- Penetration of antibiotics into prostatic tissue is crucial for successful eradication of infection.
- Azlocillin and mezlocillin are extended-spectrum penicillins with known activity against Gram-negative bacteria.
Purpose of the Study:
- To quantify the concentrations of azlocillin and mezlocillin in human prostatic tissue.
- To determine the ratio of plasma to prostatic tissue concentrations for these antibiotics.
- To assess whether achieved tissue concentrations are sufficient to inhibit common bacterial pathogens.
Main Methods:
- Two 2.0-gram doses of either azlocillin or mezlocillin were administered.
- Prostatic tissue was obtained via transurethral resection or enucleation.
- Plasma and tissue concentrations of azlocillin and mezlocillin were measured at the time of surgery.
Main Results:
- Average plasma concentrations were 64.9 µg/ml for azlocillin and 36.3 µg/ml for mezlocillin.
- Average prostatic tissue concentrations were 22.9 µg/g for azlocillin and 9.4 µg/g for mezlocillin.
- Plasma/tissue concentration ratios were 0.35 for azlocillin and 0.25 for mezlocillin.
Conclusions:
- Azlocillin and mezlocillin achieve concentrations in human prostatic tissue sufficient to inhibit common bacterial pathogens.
- Achieved tissue concentrations support the use of these antibiotics for treating bacterial prostatitis.
- Tissue concentrations were comparable regardless of the surgical method (transurethral resection or enucleation).