Gold compounds for catalysis and metal-mediated transformations in biological systems
Sophie R Thomas1, Angela Casini2
1School of Chemistry, Cardiff University, Main Building, Park Place, CF10 3AT, Cardiff, United Kingdom.
Current Opinion in Chemical Biology
|February 23, 2020
Summary
Gold complexes show promise for bio-orthogonal transformations in living systems, offering controlled reactions complementary to enzymes. These metal catalysts provide biocompatibility and stability for advanced biological and medicinal chemistry applications.
Area of Science:
- Inorganic Chemistry
- Bio-orthogonal Chemistry
- Medicinal Chemistry
Background:
- Translating metal catalysts to living systems presents challenges in biocompatibility, stability, and reactivity in aqueous environments.
- Demonstrating catalytic turnover in biological systems remains a hurdle for many metal catalysts.
- Transition metal catalysts can modulate biological processes with reactions distinct from enzymatic pathways.
Purpose of the Study:
- To explore the potential of gold complexes for bio-orthogonal transformations within living systems.
- To discuss the advantages of gold complexes, including reactivity, selectivity, and compatibility in aqueous media.
- To present examples of gold-templated reactions for biological and medicinal chemistry applications.
Main Methods:
- Review and discussion of existing literature on gold complexes in biological contexts.
- Analysis of gold coordination and organometallic complexes for bio-orthogonal applications.
- Evaluation of reactivity, selectivity, and kinetic properties in aqueous environments.
Main Results:
- Gold complexes exhibit excellent reactivity and selectivity for bio-orthogonal transformations.
- These complexes are compatible with aqueous reaction media and operate under mild conditions.
- Fast ligand exchange kinetics contribute to their efficiency in biological settings.
Conclusions:
- Gold complexes are promising tools for achieving controlled non-natural transformations in living systems.
- Their properties make them suitable for modulating bioprocesses and complementary to enzyme catalysis.
- Further applications in biological and medicinal chemistry are anticipated based on presented examples.
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