Related Experiment Video
Updated: Dec 28, 2025

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
Published on: March 23, 2022
Abstinence-contingent wage supplements to promote drug abstinence and employment: a randomised controlled trial
August F Holtyn1,2, Forrest Toegel3,2, Shrinidhi Subramaniam3,2
1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA aholtyn1@jhmi.edu.
Background:
Poverty, unemployment and substance abuse are inter-related problems. This study evaluated the effectiveness of abstinence-contingent wage supplements in promoting drug abstinence and employment in unemployed adults in outpatient treatment for opioid use disorder.
Methods:
A randomised controlled trial was conducted in Baltimore, MD, from 2014 to 2019. After a 3-month abstinence initiation and training period, participants (n=91) were randomly assigned to a usual care control group that received employment services or to an abstinence-contingent wage supplement group that received employment services plus abstinence-contingent wage supplements. All participants were invited to work with an employment specialist to seek employment in a community job for 12 months. Abstinence-contingent wage supplement participants could earn training stipends for working with the employment specialist and wage supplements for working in a community job, but had to provide opiate and cocaine-negative urine samples to maximise pay.
Results:
Abstinence-contingent wage supplement participants provided significantly more opiate and cocaine-negative urine samples than usual care control participants (65% vs 45%; OR=2.29, 95% CI 1.22 to 4.30, p=0.01) during the 12-month intervention. Abstinence-contingent wage supplement participants were significantly more likely to have obtained employment (59% vs 28%; OR=3.88, 95% CI 1.60 to 9.41, p=0.004) and lived out of poverty (61% vs 30%; OR=3.77, 95% CI 1.57 to 9.04, p=0.004) by the end of the 12-month intervention than usual care control participants.
Conclusion:
Abstinence-contingent wage supplements can promote drug abstinence and employment.
Trial Registration Number:
ClinicalTrials.gov NCT02487745.
Related Concept Videos
Drug Dependence
Drug Abuse and Addiction: Pharmacological Phenomena
Operant Conditioning Intervention
In operant conditioning, behaviors that are...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Drug Elimination: Non-Renal Routes
Community Based Intervention
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...

