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[Diabetic polyneuropathy].

D Ziegler1,2

  • 1Institut für Klinische Diabetologie, Deutsches Diabetes-Zentrum, Leibniz-Zentrum für Diabetesforschung an der Heinrich Heine-Universität, Auf'm Hennekamp 65, 40225, Düsseldorf, Deutschland. dan.ziegler@ddz.de.

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Summary
This summary is machine-generated.

Distal symmetric sensorimotor polyneuropathy (DSPN) affects one in three people with diabetes, causing pain and foot ulcers that impair quality of life. Early diagnosis and multimodal treatment are crucial for managing DSPN symptoms and improving patient well-being.

Keywords:
Blood glucoseLifestyleNeuropathic painNumbnessParesthesias

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Area of Science:

  • Neurology
  • Endocrinology
  • Diabetology

Background:

  • Distal symmetric sensorimotor polyneuropathy (DSPN) affects approximately one-third of individuals with diabetes.
  • DSPN significantly impairs quality of life due to neuropathic pain and painless foot ulcers.
  • Underdiagnosis of DSPN is a significant clinical challenge, with up to half of affected patients being asymptomatic.

Purpose of the Study:

  • To highlight the prevalence and impact of DSPN in diabetic patients.
  • To outline the key management strategies for DSPN.
  • To emphasize the importance of multimodal pain treatment for improving patient outcomes.

Main Methods:

  • Review of typical neuropathic symptoms associated with DSPN.
  • Description of the three cornerstone management approaches for DSPN.
  • Discussion of the goals of multimodal pain treatment.

Main Results:

  • DSPN is prevalent, with painful forms affecting up to 25% of diabetic patients.
  • Symptoms include pain, paresthesias, and numbness, primarily in the feet and calves.
  • Effective management requires lifestyle changes, glycemic control, risk factor intervention, pathogenesis-derived treatments, and symptomatic pain relief.

Conclusions:

  • DSPN is a common and debilitating complication of diabetes.
  • Comprehensive management involving lifestyle, causal, and symptomatic treatments is essential.
  • Multimodal pain management aims to alleviate pain and enhance overall quality of life, including sleep and mobility.