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Clonidine: placental transfer and neonatal adaption
M J Boutroy1, C R Gisonna, M Legagneur
1INSERM Unit 272, University of Nancy, France.
Early Human Development
|August 1, 1988
Summary
Clonidine readily crosses the placenta, leading to slow drug elimination in newborns. Four out of five infants experienced hypertension, possibly due to clonidine withdrawal syndrome.
Area of Science:
- Pharmacology
- Neonatal Medicine
- Obstetrics
Background:
- Clonidine is a medication used to treat hypertension.
- Understanding drug transfer during pregnancy is crucial for neonatal health.
Purpose of the Study:
- To investigate the placental transfer and neonatal effects of clonidine.
Main Methods:
- Studied five pregnancies involving clonidine exposure.
- Monitored neonates for drug elimination and clinical abnormalities.
Main Results:
- Clonidine was found to readily cross the placenta.
- Neonatal drug elimination was slow.
- Four neonates exhibited hypertension lasting at least 24 hours.
Conclusions:
- Placentally transferred clonidine can cause neonatal hypertension.
- Hypertension may be linked to a clonidine withdrawal syndrome in newborns.