MRSIGMA: Magnetic Resonance SIGnature MAtching for real-time volumetric imaging

To propose a real-time 3D MRI technique called MR SIGnature MAtching (MRSIGMA) for high-resolution volumetric imaging and motion tracking with very low imaging latency.

MRSIGMA consists of two steps: (1) offline learning of a database of possible 3D motion states and corresponding motion signature ranges and (2) online matching of new motion signatures acquired in real time with prelearned motion states. Specifically, the offline learning step (non-real-time) reconstructs motion-resolved 4D images representing different motion states and assigns a unique motion range to each state. The online matching step (real-time) acquires motion signatures only and selects one of the prelearned 3D motion states for each newly acquired signature, which generates 3D images efficiently in real time. The MRSIGMA technique was evaluated on 15 golden-angle stack-of-stars liver data sets, and the performance of respiratory motion tracking with the online-generated real-time 3D MRI was compared with the corresponding 2D projections acquired in real time.

The total latency of generating each 3D image during online matching was about 300 ms, including acquisition of the motion signature data (~138 ms) and corresponding matching process (~150 ms). Linear correlation assessment suggested excellent correlation (R²  = 0.948) between motion displacement measured from the online-generated real-time 3D images and the 2D real-time projections.

This proof-of-concept study demonstrates the feasibility of MRSIGMA for high-resolution real-time volumetric imaging, which shifts the acquisition and reconstruction burden to an offline learning step and leaves fast online matching for online imaging with very low imaging latency. The MRSIGMA technique can potentially be used for real-time motion tracking in MRI-guided radiation therapy.