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Related Concept Videos

Longitudinal Studies01:26

Longitudinal Studies

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Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
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Longitudinal Research02:20

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
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Medical Doctors and Dementia: A Longitudinal Study.

Maria Vassilaki1, Jeremy A Syrjanen1, Walter K Kremers1

  • 1Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.

Journal of the American Geriatrics Society
|February 23, 2020
PubMed
Summary
This summary is machine-generated.

This study found no significant difference in dementia risk for medical doctors (MDs) compared to the general population. Further research is needed to explore cognitive health in physicians later in life.

Keywords:
cohort studydementiamedical doctors

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Area of Science:

  • Gerontology
  • Neurology
  • Epidemiology

Background:

  • Previous research on medical doctors' (MDs) cognitive health has primarily focused on younger individuals.
  • Understanding cognitive aging in physicians is crucial for assessing long-term occupational impacts.

Purpose of the Study:

  • To investigate the association between being a medical doctor (MD) and the risk of developing incident dementia.
  • To provide preliminary insights into the cognitive health of older medical doctors.

Main Methods:

  • A population-based cohort study was conducted using data from the Mayo Clinic Study of Aging in Olmsted County, Minnesota.
  • 3460 participants aged 70 years and older, including 104 MDs, underwent regular cognitive evaluations.
  • Cox proportional hazards models were used to analyze dementia risk, adjusting for sex, education, and apolipoprotein E ε4.

Main Results:

  • Medical doctors in the study were older and predominantly male (93.3%) compared to the general population cohort.
  • No statistically significant difference in the risk of incident dementia was observed between MDs and the general population (Hazard Ratio = 1.12; 95% CI = 0.69-1.82).

Conclusions:

  • The study suggests that being a medical doctor (MD) is not associated with a significantly different risk of dementia in older age.
  • Larger longitudinal studies are recommended to confirm these findings and explore potential sex-based modifications in the association between being an MD and dementia risk.