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Related Concept Videos

Larynx01:21

Larynx

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The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Thermal Stress01:09

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If the temperature of an object is changed while it is prevented from expanding or contracting, the object is subjected to stress. The stress is compressive if the object expands in the absence of constraint and tensile if it contracts. This stress resulting from temperature change is known as thermal stress. It can be quite large and can cause damage. To avoid this stress, engineers may design components so they can expand and contract freely. For instance, on highways, gaps are deliberately...
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Related Experiment Video

Updated: Dec 28, 2025

Investigation of the Electrophysiological and Thermographic Safety Parameters of Surgical Energy Devices During Thyroid and Parathyroid Surgery in a Porcine Model
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Laryngeal Thermal Injury Model.

Gregory R Dion1,2, Christian S Pingree2, Pedro J Rico3

  • 1Dental and Craniofacial Trauma Research Department, U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas.

Journal of Burn Care & Research : Official Publication of the American Burn Association
|February 23, 2020
PubMed
Summary

This study developed a swine laryngeal burn model to evaluate thermal injury healing. Findings provide the first temporal data on laryngeal wound healing, enabling future therapeutic research.

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Area of Science:

  • Veterinary Pathology
  • Surgical Research
  • Wound Healing Models

Background:

  • Reliable models for laryngeal thermal injury are lacking, hindering research into burn wound healing and new treatments.
  • Understanding the temporal progression of laryngeal burns is crucial for developing effective interventions.

Purpose of the Study:

  • To establish and validate a swine laryngeal burn model for longitudinal evaluation of thermal injury.
  • To characterize the histological and gross changes in laryngeal thermal injuries over time.
  • To provide a foundation for future studies investigating therapeutic strategies for laryngeal burns.

Main Methods:

  • Twelve Yorkshire crossbreed swine underwent tracheostomy and induced laryngeal thermal burns using heated air (150-160°C).
  • Laryngeal tissues were assessed endoscopically and grossly at multiple time points (12 hours to 21 days).
  • Histological analysis using a nine-criteria scoring scale evaluated injury severity, inflammation, edema, and tissue repair markers.

Main Results:

  • Massive supraglottic edema and arytenoid damage were observed, extending transglottically.
  • Histological injury scores showed an inverse relationship with time post-injury, with inflammation resolving by 14 days.
  • Edema resolved by day 7, while granulation tissue and fibrosis appeared by days 3 and 7, respectively, maturing by day 14.

Conclusions:

  • The developed swine laryngeal burn model allows for longitudinal assessment of thermal injury.
  • This study presents novel temporal data on laryngeal thermal wound healing characteristics.
  • The model serves as a platform for preclinical evaluation of novel therapeutics for laryngeal burns.