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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Progress in triple negative breast carcinoma pathophysiology: Potential therapeutic targets

Kangjie Yu1, Joseph Rohr2, Yang Liu1

  • 1State Key Laboratory of Tumor Biology, Department of Pathology, Xi Jing Hospital, the Fourth Military Medical University, Xi'an, Shaan Xi Province,710032, China.

Pathology, Research and Practice
|February 24, 2020
PubMed

Insights

Triple-negative breast carcinoma (TNBC) is an aggressive cancer lacking effective treatments. This review explores emerging therapeutic targets and strategies for improving outcomes in TNBC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Triple-negative breast carcinoma (TNBC) is defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (Her2) expression.
  • TNBC is characterized by high aggressiveness, poor prognosis, and limited targeted treatment options.
  • There is a critical need for novel therapeutic strategies to improve survival rates in TNBC patients.

Purpose of the Study:

  • To review and synthesize recent scientific evidence on novel therapeutic targets for TNBC.
  • To summarize emerging and potential therapeutic regimens for treating TNBC.
  • To identify promising avenues for future TNBC treatment development.

Main Methods:

  • Comprehensive literature search of recent studies on TNBC.
  • Analysis of preclinical and clinical data supporting novel therapeutic targets.
  • Review of ongoing and proposed treatment strategies for TNBC.

Main Results:

  • Identification of several promising molecular targets implicated in TNBC pathogenesis.
  • Evaluation of novel therapeutic agents and drug combinations showing potential efficacy.
  • Summary of evidence supporting the clinical translation of these findings.

Conclusions:

  • Emerging research highlights several novel targets and therapeutic strategies for TNBC.
  • Further investigation and clinical trials are warranted to validate these findings.
  • These advancements offer hope for improved treatment outcomes in TNBC.
Keywords:
Progress in pathophysiologySignaling pathwayTherapeutic targetsTriple negative breast carcinoma (TNBC)

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