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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Dec 27, 2025

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Interfacing DNA with nanoparticles: Surface science and its applications in biosensing.

Qunye He¹, Qing Wu¹, Xiangran Feng¹

¹Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan Province, PR China.

International Journal of Biological Macromolecules

|February 24, 2020

Summary

This review details DNA-nanoparticle interactions, focusing on inorganic nanoparticles for biosensing applications. Understanding these interfacial mechanisms is key to developing advanced biosensors.

Keywords:

DNA Interfacing Nanoparticles

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Area of Science:

Nanotechnology
Biochemistry
Materials Science

Background:

DNA-nanoparticle interactions are crucial for biological applications.
Existing reviews lack systematic and detailed analysis of these interfacial phenomena.
Understanding these mechanisms is vital for advancing DNA-based nanotechnology.

Purpose of the Study:

To systematically review recent progress on DNA-nanoparticle interactions.
To elucidate fundamental principles governing these interactions.
To highlight applications in biosensing, particularly with inorganic nanoparticles.

Main Methods:

Summarized recent advancements in DNA-nanoparticle interfacial science.
Focused on inorganic nanoparticles: metal nanoparticles, carbon materials, metal oxides, and quantum dots.
Analyzed surface properties, interaction mechanisms, and DNA adsorption kinetics/spatial control.

Main Results:

Detailed understanding of DNA adsorption on various inorganic nanoparticles.
Highlighted recent biosensing technologies utilizing DNA-nanoparticle interactions.
Identified key mechanisms driving DNA-nanoparticle interfacial phenomena.

Conclusions:

Provides a systematic framework for understanding DNA-nanoparticle interactions.
Offers insights for designing improved biosensors.
Suggests future research directions in DNA-nanomaterial interfaces.