Related Experiment Video

Updated: Dec 27, 2025

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

6.7K

Cellular signaling in Abdominal Aortic Aneurysm

Zhiqing Li1, Wei Kong1

  • 1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China.

Cellular Signalling
|February 24, 2020
PubMed

Insights

Abdominal aortic aneurysms (AAAs) are lethal cardiovascular diseases with unclear molecular mechanisms. This review explores cellular signaling pathways involved in AAA pathogenesis, crucial for developing new treatments.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Cellular Signaling

Background:

  • Abdominal aortic aneurysms (AAAs) are life-threatening cardiovascular conditions lacking effective drug therapies.
  • The precise molecular and signaling mechanisms underlying AAA development remain largely unknown.
  • Pathological cellular processes like matrix remodeling, inflammation, oxidative stress, and smooth muscle cell dysfunction contribute to AAA formation.

Purpose of the Study:

  • To review the role of cellular signaling networks in the pathogenesis and progression of AAAs.
  • To elucidate the complex interplay between cellular signaling and AAA development.
  • To highlight the importance of understanding signaling pathway crosstalk for therapeutic advancements.

Main Methods:

  • Literature review focusing on cellular signaling pathways in AAA.
  • Analysis of molecular and cellular mechanisms contributing to AAA pathogenesis.
  • Synthesis of information on key signaling cascades including NF-κB, MAPK, TGFβ, Notch, and inflammasome.

Main Results:

  • Cellular signaling pathways such as NF-κB, MAPK, TGFβ, Notch, and inflammasome are integral to AAA pathogenesis.
  • These pathways mediate critical cellular processes including extracellular matrix remodeling, inflammation, oxidative stress, and vascular smooth muscle cell dysfunction.
  • Complex interactions and crosstalk between signaling networks significantly influence AAA progression.

Conclusions:

  • Understanding the intricate cellular signaling networks is vital for unraveling AAA pathogenesis.
  • Targeting specific signaling pathways and their interactions offers potential for novel therapeutic strategies.
  • Elucidating these mechanisms is essential for developing personalized treatments for AAA diseases.
Keywords:
Abdominal Aortic AneurysmCellular signalingExtracellular matrix remodelingInflammationOxidative stressVascular smooth muscle cells

More Related Videos

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases04:59

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Published on: June 20, 2025

701
Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions06:08

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Published on: March 8, 2019

20.5K

Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
193
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
151
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
220
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
51.7K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.4K
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
67.5K