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An effective method for the determination of the enantio-purity of L-α-glycerophosphocholine (L-α-GPC)
Lorenzo de Ferra1, Antonio Massa2, Antonia Di Mola2
1Chemi SpA, Via Vadisi, 5 03010, FR, Italy.
Journal of Pharmaceutical and Biomedical Analysis
|February 24, 2020
Abstract:
Herein we describe for the first time a practical analytical method for determining the enantio-purity of L-α-glycerophosphocholine (L-α-GPC) by chiral derivatization. The use of a suitable chiral boronic acid allowed the formation of a mixture of two diastereomeric boronate esters whose ratio, carefully analyzed by 1HNMR spectroscopy, reflects L-α-GPC enantiomeric excesses. The determination of the enantiopurity of L-α-GPC furnishes convincing correlations with its manufacturing process.

