[Mechanisms of the anti-anginal effect of korinfar]

Some clinical, hemodynamic and biochemical parameters were studied in 25 patients with ischemic heart disease of II-III functional classes depending on the presence of the antianginal effect during paired loading pharmacodynamic tests with corinfar. The antianginal effect of corinfar was found to be associated with a marked growth of "double product" and the presence of a clinical symptom of adaptation. In patients with the lack of corinfar antianginal effect there were noted the adaptation symptom absence and a higher blood catecholamine level. A decrease of the postloading did not correlate with the drug antianginal effect. The data could indicate that in the mechanism of corinfar antianginal effect the determining factor is its direct influence on the coronary circulation.