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Formulation and clinical evaluation of the standardized Litchi chinensis extract for skin hyperpigmentation and aging
N Lourith1, M Kanlayavattanakul1
1School of Cosmetic Science, Mae-Fah-Luang University, 57100 Chiang-Rai, Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae-Fah-Luang University, 57100 Chiang-Rai, Thailand.
Introduction:
The standardized litchi extract had been revealed on phytochemical actives, in vitro and cellular activities against aging and darkening of skin. However, a formulation containing the extract has never been developed as per clinical evaluated.
Materials And Methods:
The litchi serum was developed, safety and efficacy were clinically evaluated in human volunteers. The stable and none irritated 0.05 and 0.1% litchi serums were randomized-single blind placebo control clinical applied on the inner forearm of 29 volunteers for a consecutive 112 days and monitored by Mexameter® MX18, Cutometer® MPA 580 and Visioscan® VC 98.
Results:
Skin lightening efficacy of the 0.1% and 0.05% litchi serum was significantly (P<0.001 and P<0.05) higher than the placebo. Skin elasticity and wrinkle reduction was significantly (P<0.05 and P<0.005) achieved by the 0.1% litchi serum. The efficacy of litchi serums was confirmed by a split-face, randomized, single-blind controlled that the 0.1% litchi serum was significantly (P<0.05) better than the 0.05% one of all examined parameters.
Conclusion:
Safety and efficacy of litchi extract are clinically confirmed for hyperpigmentation and aging of skin treatments.
