Related Experiment Video
Updated: Dec 27, 2025
Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
Published on: April 3, 2018
High Glucose Exacerbates TNF-α-Induced Proliferative Inhibition in Human Periodontal Ligament Stem Cells through
Wenjun Zhu1,2, Qihong Qiu1,2, Haoyuan Luo1,2
1Department of Periodontology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
Objective:
This research is aimed at investigating how high glucose affects the proliferation and apoptosis in periodontal ligament stem cells (PDLSCs) in the presence of TNF-α.
Methods:
PDLSCs obtained from periodontal healthy permanent teeth were treated under either high-glucose condition (30 mmol/L, G30 group) or normal glucose condition (5.6 mmol/L, G5.6 group) in the presence or absence of TNF-α. α. α.
Results:
CCK-8 assay showed that high glucose exacerbated TNF-α. α. α. α. α. α.
Conclusion:
High glucose exacerbates TNF-α-induced proliferative inhibition in human periodontal ligament stem cells through the upregulation and activation of TNF receptor 1. Inhibition of intracellular ROS expression by vitamin C partially rescues PDLSCs in terms of cell proliferation.α.
Related Concept Videos
01:16TGF - β Signaling Pathway
01:24T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:09GPCRs Regulate Adenylyl Cylase Activity