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Tannase-Converted Green Tea Extract with High (-)-Epicatechin Inhibits Skeletal Muscle Mass in Aged Mice
Ki-Bae Hong1, Hee-Seok Lee2, Dong Hyeon Kim3
1BK21 Plus, College of Health Science, Korea University, Seoul 02841, Republic of Korea.
Evidence-Based Complementary and Alternative Medicine : Ecam
|February 25, 2020
Summary
High-dose tannase-converted green tea extract significantly increased lean body mass and muscle differentiation factors. This extract also enhanced antioxidant enzyme expression, suggesting it prevents muscle loss more effectively than epicatechin.
Area of Science:
- Biochemistry
- Exercise Physiology
- Nutraceuticals
Background:
- Green tea extract is known for its health benefits.
- Tannase conversion may enhance the bioavailability of green tea compounds.
- Muscle mass and oxidative stress are crucial factors in aging and disease.
Purpose of the Study:
- To evaluate the impact of tannase-converted green tea extract on body composition.
- To assess its effects on muscle oxidative stress markers.
- To investigate its influence on muscle differentiation factors.
Main Methods:
- Dual-energy X-ray absorptiometry (DEXA) for body composition.
- Quantitative real-time polymerase chain reaction (qRT-PCR) for gene expression.
- Western blotting for protein analysis.
Main Results:
- High-dose extract significantly increased lean body mass compared to controls.
- Muscle differentiation and SOD gene expression were upregulated by the extract.
- Tannase-converted green tea extract showed superior effects compared to epicatechin.
Conclusions:
- Tannase-converted green tea extract effectively prevents muscle loss.
- It regulates muscle quantity and quality via antioxidant and differentiation pathways.
- This extract holds promise as a supplement for muscle health.
