Related Experiment Video
Updated: Dec 27, 2025

Generation and Multi-phenotypic High-content Screening of Coxiella burnetii Transposon Mutants
Published on: May 13, 2015
A Deterministic Model for Q Fever Transmission Dynamics within Dairy Cattle Herds: Using Sensitivity Analysis and
Joshua Kiddy K Asamoah1, Zhen Jin1, Gui-Quan Sun1
1Complex Systems Research Center, Shanxi University, Taiyuan 030006, China.
Abstract:
This paper presents a differential equation model which describes a possible transmission route for Q fever dynamics in cattle herds. The model seeks to ascertain epidemiological and theoretical inferences in understanding how to avert an outbreak of Q fever in dairy cattle herds (livestock). To prove the stability of the model's equilibria, we use a matrix-theoretic method and a Lyapunov function which establishes the local and global asymptotic behaviour of the model. We introduce time-dependent vaccination, environmental hygiene, and culling and then solve for optimal strategies. The optimal control strategies are necessary management practices that may increase animal health in a Coxiella burnetii-induced environment and may also reduce the transmission of the disease from livestock into the human population. The sensitivity analysis presents the relative importance of the various generic parameters in the model. We hope that the description of the results and the optimality trajectories provides some guidelines for animal owners and veterinary officers on how to effectively minimize the bacteria and control cost before/during an outbreak.
More Related Videos
09:57Development and Validation of a Quantitative PCR Method for Equid Herpesvirus-2 Diagnostics in Respiratory Fluids
Published on: March 17, 2016
10:29Applying Fluorescence Resonance Energy Transfer FRET to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing
Published on: July 6, 2016
Related Concept Videos
Steps in Outbreak Investigation
Mechanistic Models: Compartment Models in Individual and Population Analysis
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses