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Updated: Dec 27, 2025

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
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Refining Cancer Management Using Integrated Liquid Biopsy.

Juhui Qiu1, Jianxiong Xu1, Kang Zhang1

  • 1Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400044, China.

Theranostics
|February 25, 2020
PubMed
Summary
This summary is machine-generated.

Integrated liquid biopsy using multiple biomarkers overcomes inconsistencies in cancer detection. This novel framework enhances early diagnosis, metastasis surveillance, and prognostication for improved patient outcomes.

Keywords:
Cancer managementCirculating tumor DNACirculating tumor cellCombined detectionExtracellular vesicle.

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Area of Science:

  • Oncology
  • Biomarker Discovery
  • Molecular Diagnostics

Background:

  • Liquid biopsy offers a noninvasive approach for cancer diagnosis and monitoring.
  • Conventional single-biomarker liquid biopsy methods face challenges due to analytical inconsistencies and intratumoral heterogeneity.
  • There is a growing need for more robust and reliable liquid biopsy strategies.

Purpose of the Study:

  • To review advancements in liquid biopsy technologies.
  • To propose a novel integrated liquid biopsy framework for improved cancer management.
  • To outline a roadmap for refining cancer diagnosis, metastasis surveillance, and prognostication.

Main Methods:

  • Comprehensive literature review of liquid biopsy advancements.
  • Development of a tiered framework for integrated liquid biopsy: elementary, intermediate, and advanced.
  • Analysis of the benefits of integrating multiple biomarkers in liquid biopsy.

Main Results:

  • Integrated detection of multiple liquid biopsy biomarkers significantly improves diagnostic performance.
  • The proposed framework addresses inconsistencies arising from diverse analytical methodologies.
  • Integration strategies effectively mitigate the impact of intratumoral heterogeneity.

Conclusions:

  • Integrated liquid biopsy represents a significant advancement over conventional methods.
  • The proposed framework provides a structured approach to enhance cancer detection and monitoring.
  • Further development and validation of integrated liquid biopsy hold promise for personalized cancer care.