Related Experiment Video
Updated: Dec 27, 2025
07:18
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
Published on: June 13, 2019
7.3K
Cytokeratin-Positive Osteosarcoma Simulating Sarcomatoid Metastatic Carcinoma
Hamza Murtaza1, Abdul Rehman Arain1, Afshin Anoushiravani1
1Albany Medical Center, Albany NY, USA.
Case Reports in Orthopedics
|February 25, 2020
Summary
Cytokeratin-positive osteosarcoma is rare and can be misdiagnosed as metastatic carcinoma. This case highlights the importance of considering osteosarcoma in cytokeratin-positive bone neoplasms, especially with malignant osteoid formation.
Area of Science:
- Oncology
- Pathology
- Orthopedic Surgery
Background:
- Osteosarcoma is the most common primary malignant bone tumor.
- Cytokeratin positivity is rare in osteosarcoma, complicating diagnosis.
- Distinguishing cytokeratin-positive osteosarcoma from metastatic carcinoma is challenging.
Observation:
- A 52-year-old male presented with a destructive distal femoral lesion.
- Initial diagnosis was metastatic sarcomatoid carcinoma based on radiographic and histopathologic findings.
- Surgical resection revealed high-grade conventional osteosarcoma with intense cytokeratin positivity.
Findings:
- The osteosarcoma exhibited unusual, diffuse cytokeratin positivity.
- This rare immunohistochemical finding complicated the initial diagnosis.
- Histological evidence of malignant osteoid formation was crucial.
Implications:
- This case underscores the diagnostic challenge posed by cytokeratin-positive osteosarcoma.
- Integrating clinical, radiological, and histological data is vital for accurate diagnosis.
- Awareness of this rare presentation aids in differentiating it from metastatic carcinoma.
